Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-la. Characterization of cells with osteogenic potential from human marrow. Haynesworth SE GJ, Goldberg VM, Caplan AI. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MS Cs) and stromal cells. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. J Hemathother Stem Cell Res 2001 9: 841–848. Human marrow-derived mesenchymal stem cells express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. Majumdar M, Thiede M, Haynesworth S, Bruder S, Gerson S. Origin of bone marrow stromal mechanocytes in radiochimeras and heterotopic transplants. Blood 1999 94: 377a.įriedenstein A, Ivanov-Smolenski A, Chajlakjan R, Gorskaya U, Kuralesova A, Latzinik N, et al. Turning marrow into brain: generation of glial and neuronal cells from adult bone marrow mesenchymal stem cells. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats similarities to astrocyte grafts. Nature Med 2000 6: 1229–1234.Īzizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Lagasse E, Conners H, Al-Dhalimy M, Reitsma M, Dolhse M, Osbourne L, et al. Bone marrow as a potential source of hepatic oval cells. Petersen B, Bowen W, Patrene K, Mars W, Sullivan A, Murase N, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Ann NY Acad Sci 1995 770: 70–88.įerrari G, Cusella-DeAngelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, et al. Support of human hematopoiesis in long term bone marrow cultures by murine stromal cells selectively expressing the membrane bound and secreted forms of the human homologue of the steel gene product, stem cell factor. Toksoz D, Zsebo K, Smith K, Hu S, Brankow D, Suggs S, et al. The chondrogenic potential of human bone marrow-derived mesenchymal progenitor cells. Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan A, Goldberg VM, et al. Multilineage potential of adult human mesenchymal stem cells. Pittinger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J, et.al. Marrow stromal cells as stem cells for nonhematopoietic tissues. Bone 1992 13: 69–80.īianco P, Constantini M, Dearden L, Bonucci E Alkaline phosphatase positive precursors of adipocytes in the human bone marrow. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. There is growing interest in cotransplantation of allogeneic mesenchymal and hematopoietic progenitors to facilitate hematopoietic engraftment and limit GVHD. Such cells fabricate the connective tissue scaffolding and produce cytokines, chemokines, and extracellular matrix proteins that regulate hematopoietic homing and proliferation (6,7). It is thought that these progenitors, called mesenchymal stem cells, give rise to adventitial and other mesenchymal cells in the marrow and constitute the microenvironment for hematopoiesis. Several groups have described nonhematopoietic plastic-adherent progenitor cells derived from human bone marrow aspirates, which are capable of differentiating into mature mesenchymal cells (1–5). This chapter will introduce a novel cellular therapy, which may address these problems, particularly in high risk patients such as those receiving marginal numbers of hematopoietic progenitor cells (i.e., umbilical cord blood ) and those receiving unrelated donor or related but human leukocyte antigen (HLA)-mismatched donor progenitor cells. Graft failure and graft-vs-host disease (GVHD) remain significant obstacles to successful outcome in patients undergoing allogeneic hematopoietic stem cell transplantation.
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